Ein kleines Hotel am Strand von Fehmarn, eine chaotisch-liebenswerte Familie und jede Menge Heiratsanträge - ein sommerlich-humorvoller Roman mit bezauberndem Schauplatz "Emily, glaub mir. Ich bilde mir das nicht ein: Das Hotel steckt in großen Schwierigkeiten." Der unerwartete Hilferuf ihrer Mutter und die Bitte, rasch nach Hause zu kommen, bringen Emily völlig aus dem Konzept. Zwar hat sie Fehmarn vor Jahren den Rücken gekehrt, das kleine Familienhotel am Strand liegt ihr aber noch immer am Herzen. So aufgeregt ist Emily, dass ihr erst viel später auffällt, dass ihr Freund ihr gerade einen Antrag machen wollte. Nicht das beste Vorzeichen für ihren Plan, die "Strandperle" in ein Romantikhotel umzuwandeln und Verliebten bei der Organisation des perfekten Heiratsantrags zu helfen ... Product details Format ...
The first useful antibiotic found by screening was streptomycin. The late Prof. WAKSMAN started screening for antibacterial antibiotics in 1940 and, after finding actinomycin in 1941, he and his collaborators discovered streptomycin in 1944. This antibiotic made a great contribution in saving human lives from tuberculosis and acute serious infections. About 1957, after wide usage of such antibiotics as penicillin, streptomycin, chloramphenicol, tetracycline, and erythromycin, staphy- lococci and Gram negative organisms resistant to all or most antibiotic drugs ap- peared in hospital patients. The origin and treatment of such resistant strains be- came a major topic of investigation. At that time, kanamycin was discovered and used in the treatment of resistant infections. It may be said that the appearance of resistant strains stimulated a resurgence of research on new antibacterial antibiot- ics and their derivatives.
In 1965, kanamycin-resistant strains were found in hospital patients and, undertaking the study of the mechanisms of resistance, I found that resistant strains produce intracellular enzymes that can transfer either the terminal phos- phate of ATP or the acetate of acetyl-CoA to the 3' -hydroxyl or the 6' -amino group of 2-deoxystreptamine~containing antibiotics. These results, reported in 1967, made it possible to design new synthetic derivatives that would inhibit the growth of kanamycin resistant strains of microorganisms. Thus, a new research area was opened: the development of aminoglycosides useful in the treatment of drug-resis- tant infections.
Product details
- Paperback | 372 pages
- 170 x 244 x 20.57mm | 675g
- 18 Nov 2011
- Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
- Springer-Verlag Berlin and Heidelberg GmbH & Co. K
- Berlin, Germany
- English
- Softcover reprint of the original 1st ed. 1982
- XVI, 372 p.
- 3642685811
- 9783642685811
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